2kap: Difference between revisions
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==Solution structure of DLC1-SAM== | ==Solution structure of DLC1-SAM== | ||
<StructureSection load='2kap' size='340' side='right'caption='[[2kap | <StructureSection load='2kap' size='340' side='right'caption='[[2kap]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2kap]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2kap]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KAP FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kap OCA], [https://pdbe.org/2kap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kap RCSB], [https://www.ebi.ac.uk/pdbsum/2kap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kap ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kap OCA], [https://pdbe.org/2kap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kap RCSB], [https://www.ebi.ac.uk/pdbsum/2kap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kap ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/RHG07_HUMAN RHG07_HUMAN] Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.<ref>PMID:18786931</ref> <ref>PMID:19170769</ref> <ref>PMID:19710422</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Yang | [[Category: Yang D]] | ||
[[Category: Yang | [[Category: Yang S]] | ||