1a66: Difference between revisions
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'''SOLUTION NMR STRUCTURE OF THE CORE NFATC1/DNA COMPLEX, 18 STRUCTURES'''<br /> | '''SOLUTION NMR STRUCTURE OF THE CORE NFATC1/DNA COMPLEX, 18 STRUCTURES'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1A66 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1A66 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A66 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: transcription factor]] | [[Category: transcription factor]] | ||
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Revision as of 16:28, 15 February 2008
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SOLUTION NMR STRUCTURE OF THE CORE NFATC1/DNA COMPLEX, 18 STRUCTURES
OverviewOverview
The nuclear factor of the activated T cell (NFAT) family of transcription, factors regulates cytokine gene expression by binding to the, promoter/enhancer regions of antigen-responsive genes, usually in, cooperation with heterologous DNA-binding partners. Here we report the, solution structure of the binary complex formed between the core, DNA-binding domain of human NFATC1 and the ARRE2 DNA site from the, interleukin-2 promoter. The structure reveals that DNA binding induces the, folding of key structural elements that are required for both, sequence-specific recognition and the establishment of cooperative, protein-protein contacts. The orientation of the NFAT DNA-binding domain, observed in the binary NFATC1-DBD*/ DNA complex is distinct from that seen, in the ternary NFATC2/AP-1/DNA complex, suggesting that the domain, reorients upon formation of a cooperative transcriptional complex.
About this StructureAbout this Structure
1A66 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Solution structure of the core NFATC1/DNA complex., Zhou P, Sun LJ, Dotsch V, Wagner G, Verdine GL, Cell. 1998 Mar 6;92(5):687-96. PMID:9506523
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