Aminoacyl tRNA Synthetase: Difference between revisions
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== 3D Structures of Aminoacyl tRNA synthetase == | == 3D Structures of Aminoacyl tRNA synthetase == | ||
[[Aminoacyl tRNA synthetase 3D structures]] | [[Aminoacyl tRNA synthetase 3D structures]] | ||
One very interesting question in biology is how does an aminoacyl-tRNA synthetase recognize a particular tRNA and charge it with the correct amino acid? This is a challenging problem, since all tRNAs have the same general structure. Interestingly, different tRNA synthetases accomplish this goal in different ways. | |||
The <scene name='44/444597/Protein_surface_interaction/1'>glutaminyl-tRNA synthetase</scene> (GlnRS) interacts with both the anticodon loop and the acceptor stem. Genetic and biochemical data indicate that GlnRS interacts with all three bases of the <scene name='44/444597/Anticodon_loop/1'>anticodon loop</scene>, which are unstacked and splay outward so they can bind in separate recognition pockets of GlnRS. The 3' end of tRNAgln plunges deeply into a protein pocket that also binds the enzymes ATP and glutamine substrates. | |||
</StructureSection> | </StructureSection> | ||