2gnq: Difference between revisions
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<StructureSection load='2gnq' size='340' side='right'caption='[[2gnq]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='2gnq' size='340' side='right'caption='[[2gnq]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2gnq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2gnq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GNQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GNQ FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gnq OCA], [https://pdbe.org/2gnq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gnq RCSB], [https://www.ebi.ac.uk/pdbsum/2gnq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gnq ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gnq OCA], [https://pdbe.org/2gnq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gnq RCSB], [https://www.ebi.ac.uk/pdbsum/2gnq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gnq ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Allali-Hassani | [[Category: Allali-Hassani A]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Bochkarev | [[Category: Bochkarev A]] | ||
[[Category: Edwards | [[Category: Edwards AM]] | ||
[[Category: Loppnau | [[Category: Loppnau P]] | ||
[[Category: Min | [[Category: Min J]] | ||
[[Category: Plotnikov | [[Category: Plotnikov AN]] | ||
[[Category: Schuetz A]] | |||
[[Category: Schuetz | [[Category: Sundstrom M]] | ||
[[Category: Sundstrom | [[Category: Vedadi M]] | ||
[[Category: Vedadi | [[Category: Weigelt J]] | ||
[[Category: Weigelt | |||