6oon: Difference between revisions

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<StructureSection load='6oon' size='340' side='right'caption='[[6oon]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='6oon' size='340' side='right'caption='[[6oon]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6oon]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ ] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OON FirstGlance]. <br>
<table><tr><td colspan='2'>[[6oon]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OON FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AGO4, EIF2C4, KIAA1567 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6oon FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oon OCA], [https://pdbe.org/6oon PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6oon RCSB], [https://www.ebi.ac.uk/pdbsum/6oon PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6oon ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6oon FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oon OCA], [https://pdbe.org/6oon PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6oon RCSB], [https://www.ebi.ac.uk/pdbsum/6oon PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6oon ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/AGO4_HUMAN AGO4_HUMAN]] Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV).[HAMAP-Rule:MF_03033]<ref>PMID:15337849</ref> <ref>PMID:18552826</ref> <ref>PMID:18771919</ref>
[https://www.uniprot.org/uniprot/AGO4_HUMAN AGO4_HUMAN] Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV).[HAMAP-Rule:MF_03033]<ref>PMID:15337849</ref> <ref>PMID:18552826</ref> <ref>PMID:18771919</ref>  
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Brackbill, J A]]
[[Category: Brackbill JA]]
[[Category: Nakanishi, K]]
[[Category: Nakanishi K]]
[[Category: Park, M S]]
[[Category: Park MS]]
[[Category: Hydrolase-rna complex]]
[[Category: Mirna]]
[[Category: Rna]]
[[Category: Rna binding protein]]

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