2fmp: Difference between revisions
No edit summary |
No edit summary |
||
| Line 3: | Line 3: | ||
<StructureSection load='2fmp' size='340' side='right'caption='[[2fmp]], [[Resolution|resolution]] 1.65Å' scene=''> | <StructureSection load='2fmp' size='340' side='right'caption='[[2fmp]], [[Resolution|resolution]] 1.65Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2fmp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2fmp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FMP FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DCT:2,3-DIDEOXYCYTIDINE+5-TRIPHOSPHATE'>DCT</scene>, <scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fmp OCA], [https://pdbe.org/2fmp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fmp RCSB], [https://www.ebi.ac.uk/pdbsum/2fmp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fmp ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fmp OCA], [https://pdbe.org/2fmp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fmp RCSB], [https://www.ebi.ac.uk/pdbsum/2fmp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fmp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 33: | Line 31: | ||
==See Also== | ==See Also== | ||
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]] | |||
*[[DNA polymerase beta|DNA polymerase beta]] | *[[DNA polymerase beta|DNA polymerase beta]] | ||
== References == | == References == | ||
| Line 38: | Line 37: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Batra | [[Category: Batra VK]] | ||
[[Category: Beard | [[Category: Beard WA]] | ||
[[Category: Krahn | [[Category: Krahn JM]] | ||
[[Category: Pedersen | [[Category: Pedersen LC]] | ||
[[Category: Shock | [[Category: Shock DD]] | ||
[[Category: Wilson | [[Category: Wilson SH]] | ||