2fji: Difference between revisions

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<StructureSection load='2fji' size='340' side='right'caption='[[2fji]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='2fji' size='340' side='right'caption='[[2fji]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2fji]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FJI FirstGlance]. <br>
<table><tr><td colspan='2'>[[2fji]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FJI FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SEC6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fji OCA], [https://pdbe.org/2fji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fji RCSB], [https://www.ebi.ac.uk/pdbsum/2fji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fji ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fji OCA], [https://pdbe.org/2fji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fji RCSB], [https://www.ebi.ac.uk/pdbsum/2fji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fji ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/SEC6_YEAST SEC6_YEAST]] Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.  
[https://www.uniprot.org/uniprot/SEC6_YEAST SEC6_YEAST] Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fji ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fji ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The exocyst is a conserved protein complex essential for trafficking secretory vesicles to the plasma membrane. The structure of the C-terminal domain of the exocyst subunit Sec6p reveals multiple helical bundles, which are structurally and topologically similar to Exo70p and the C-terminal domains of Exo84p and Sec15, despite &lt;10% sequence identity. The helical bundles appear to be evolutionarily related molecular scaffolds that have diverged to create functionally distinct exocyst proteins.
The structure of the exocyst subunit Sec6p defines a conserved architecture with diverse roles.,Sivaram MV, Furgason ML, Brewer DN, Munson M Nat Struct Mol Biol. 2006 Jun;13(6):555-6. Epub 2006 May 14. PMID:16699513<ref>PMID:16699513</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2fji" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 18824]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Munson, M]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Sivaram, M V]]
[[Category: Munson M]]
[[Category: Endocytosis-exocytosis complex]]
[[Category: Sivaram MV]]
[[Category: Exocyst complex]]
[[Category: Exocytosis]]
[[Category: Tandem helical bundle]]

Latest revision as of 12:23, 14 February 2024

Crystal structure of the C-terminal domain of the exocyst subunit Sec6pCrystal structure of the C-terminal domain of the exocyst subunit Sec6p

Structural highlights

2fji is a 2 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SEC6_YEAST Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

2fji, resolution 2.40Å

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OCA
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