1dsl: Difference between revisions

Revision as of 23:33, 30 June 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1dsl.png

Template:STRUCTURE 1dsl

GAMMA B CRYSTALLIN C-TERMINAL DOMAINGAMMA B CRYSTALLIN C-TERMINAL DOMAIN

Template:ABSTRACT PUBMED 8605629

About this StructureAbout this Structure

1DSL is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

ReferenceReference

The X-ray structures of two mutant crystallin domains shed light on the evolution of multi-domain proteins., Norledge BV, Mayr EM, Glockshuber R, Bateman OA, Slingsby C, Jaenicke R, Driessen HP, Nat Struct Biol. 1996 Mar;3(3):267-74. PMID:8605629

Page seeded by OCA on Mon Jun 30 23:33:11 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1dsl.gif|left|200px]]
+{{Seed}}
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 {{STRUCTURE_1dsl|  PDB=1dsl  |  SCENE=  }}
-'''GAMMA B CRYSTALLIN C-TERMINAL DOMAIN'''
+===GAMMA B CRYSTALLIN C-TERMINAL DOMAIN===
-==Overview==
+<!--
-We use protein engineering and crystallography to simulate aspects of the early evolution of beta gamma-crystallins by observing how a single domain oligomerizes in response to changes in a sequence extension. The crystal structure of the C-terminal domain of gamma beta-crystallin with its four-residue C-terminal extension shows that the domain does not form a symmetric homodimer analogous to the two-domain pairing in beta gamma-crystallins. Instead the C-terminal extension now forms heterologous interactions with other domains leading to the solvent exposure of the natural hydrophobic interface with a consequent loss in protein solubility. However, this domain truncated by just the C-terminal tyrosine forms a symmetric homodimer of domains in the crystal lattice.
+The line below this paragraph, {{ABSTRACT_PUBMED_8605629}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8605629 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8605629}}
 ==About this Structure==
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 [[Category: Eye lens protein]]
 [[Category: Multigene family]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:13:26 2008''
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