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==== | ==Crystal structure of 4493 Fab in complex with circumsporozoite protein DND and anti-kappa VHH domain== | ||
<StructureSection load='6o2b' size='340' side='right'caption='[[6o2b]]' scene=''> | <StructureSection load='6o2b' size='340' side='right'caption='[[6o2b]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[6o2b]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O2B FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o2b OCA], [https://pdbe.org/6o2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o2b RCSB], [https://www.ebi.ac.uk/pdbsum/6o2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o2b ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o2b OCA], [https://pdbe.org/6o2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o2b RCSB], [https://www.ebi.ac.uk/pdbsum/6o2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o2b ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/CSP_PLAFO CSP_PLAFO] The circumsporozoite protein is the immunodominant surface antigen on the sporozoite (the infective stage of the malaria parasite that is transmitted from the mosquito to the vertebrate host). | |||
==See Also== | |||
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Lama glama]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Plasmodium falciparum]] | ||
[[Category: Bosch A]] | |||
[[Category: Julien JP]] | |||
[[Category: Murugan R]] | |||
[[Category: Prieto K]] | |||
[[Category: Scally SW]] | |||
[[Category: Wardemann H]] | |||
Revision as of 10:07, 3 April 2024
Crystal structure of 4493 Fab in complex with circumsporozoite protein DND and anti-kappa VHH domainCrystal structure of 4493 Fab in complex with circumsporozoite protein DND and anti-kappa VHH domain
Structural highlights
FunctionCSP_PLAFO The circumsporozoite protein is the immunodominant surface antigen on the sporozoite (the infective stage of the malaria parasite that is transmitted from the mosquito to the vertebrate host). See Also |
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