SARS-CoV-2 spike protein mutations: Difference between revisions

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Eric Martz

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 :4. <scene name='87/870593/Spike_open/5'>P681H: Pro 681 to His</scene>. This mutation is in the [[SARS-CoV-2 spike protein priming by furin|furin cleavage site that primes spike protein]]. The effects of this mutation are not yet known.
-====501Y.V2====
+====B.1.351====
-The 501Y.V2 lineage (also called 501.V2 or B.1.351) accounted for more than half of new cases in South Africa in late December, 2020<ref name="gisaid1" />. This lineage is also suspected to have a higher rate of transmission. Its mutations of greatest concern include one in common with B.1.1.7 (N501Y) plus two different mutations that are, like N501Y, in the receptor binding domain of the spike protein:
+The B.1.351 lineage (also called '''501Y.V2''' or 501.V2) accounted for more than half of new cases in South Africa in late December, 2020<ref name="gisaid1" />. This lineage is also suspected to have a higher rate of transmission. Its mutations of greatest concern include one in common with B.1.1.7 (N501Y) plus two different mutations that are, like N501Y, in the receptor binding domain of the spike protein:
 :<scene name='87/870593/Spike_open/7'>N501Y plus K417N and E484K</scene><ref name="gisaid1" />.
 These mutations also increase binding affinity for ACE2<ref name="zahradnik" />. Unlike B.1.1.7, 501Y.V2 retains His 69 and Val 70 (not deleted)<ref name="cdc1" />.
-====L452R====
+====B.1.429====
-The lineage including spike protein mutation L452R increased from 4% to 25% of samples in Northern California, USA, by mid-January, 2021<ref name="santaclara" /><ref name="deadline" />. <scene name='87/870593/Spike_open/9'>Position 452 is in the ACE2 receptor-binding region.</scene> L452R confers resistance to convalescent serum antibodies<ref name="convalescent">PMID: 33442690</ref>, but its effect on T cell immunity is not known.
+The lineage including spike protein mutation '''L452R''' increased from 4% to 25% of samples in Northern California, USA, by mid-January, 2021<ref name="santaclara" /><ref name="deadline" />. <scene name='87/870593/Spike_open/9'>Position 452 is in the ACE2 receptor-binding region.</scene> L452R confers resistance to convalescent serum antibodies<ref name="convalescent">PMID: 33442690</ref>, but its effect on T cell immunity is not known.
 ====Q677P/H====