1dqt: Difference between revisions

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OCA

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-[[Image:1dqt.gif|left|200px]]
+{{Seed}}
+[[Image:1dqt.png|left|200px]]
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 {{STRUCTURE_1dqt|  PDB=1dqt  |  SCENE=  }}
-'''THE CRYSTAL STRUCTURE OF MURINE CTLA4 (CD152)'''
+===THE CRYSTAL STRUCTURE OF MURINE CTLA4 (CD152)===
-==Overview==
+<!--
-The effective regulation of T cell responses is dependent on opposing signals transmitted through two related cell-surface receptors, CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). Dimerization of CTLA-4 is required for the formation of high-avidity complexes with B7 ligands and for transmission of signals that attenuate T cell activation. We determined the crystal structure of the extracellular portion of CTLA-4 to 2.0 angstrom resolution. CTLA-4 belongs to the immunoglobulin superfamily and displays a strand topology similar to Valpha domains, with an unusual mode of dimerization that places the B7 binding sites distal to the dimerization interface. This organization allows each CTLA-4 dimer to bind two bivalent B7 molecules and suggests that a periodic arrangement of these components within the immunological synapse may contribute to the regulation of T cell responsiveness.
+The line below this paragraph, {{ABSTRACT_PUBMED_11052947}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11052947 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11052947}}
 ==About this Structure==
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 [[Category: Homodimer]]
 [[Category: Immunoglobulin variable domain-like beta-sandwich]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:10:06 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:28:57 2008''