Mycobacterium Tuberculosis Transpeptidase Domain: Difference between revisions
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==Mtb Transpeptidase Domain in Complex with Penicillin== | ==Mtb Transpeptidase Domain in Complex with Penicillin== | ||
<StructureSection load='5cxw' size='340' side='right' caption='M. tuberculosis penicillin-binding protein peptidase domain complex with penicillin V, | <StructureSection load='5cxw' size='340' side='right' caption='M. tuberculosis penicillin-binding protein peptidase domain complex with penicillin V, HEPES and PEG (PDB code [[5cxw]]).' scene=''> | ||
Tuberculosis (TB) is one of the major human respiratory diseases which is caused by ''Mycobacterium Tuberculosis''. The infection of M. tuberculosis causes a large area of necrosis of pulmonary tissue, which results in significant breathing difficulties. TB is also known to be a major causing agent for chronic obstructive pulmonary disease (COPD). Nowadays, TB proposes a significant problem in antibiotic resistance, traditional antibiotics gradually become less and less effective towards the antibiotic-resistant strain of M. tuberculosis. In order to develop a novel antibiotic, further research has led us into the mechanism of how known antibiotic acts on M. tuberculosis. A new therapeutic approach is taken by investigating the penicillium binding site PonA1. | Tuberculosis (TB) is one of the major human respiratory diseases which is caused by ''Mycobacterium Tuberculosis''. The infection of M. tuberculosis causes a large area of necrosis of pulmonary tissue, which results in significant breathing difficulties. TB is also known to be a major causing agent for chronic obstructive pulmonary disease (COPD). Nowadays, TB proposes a significant problem in antibiotic resistance, traditional antibiotics gradually become less and less effective towards the antibiotic-resistant strain of M. tuberculosis. In order to develop a novel antibiotic, further research has led us into the mechanism of how known antibiotic acts on M. tuberculosis. A new therapeutic approach is taken by investigating the penicillium binding site PonA1. | ||