Sandbox GGC9: Difference between revisions

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== Function ==
== Function ==
 
RAG1 and RAG2 form the RAG Complex, which is responsible for regulating the DNA cleavage phase during recombination. V(D)J recombination functions to produce a plethora of immune molecules (antibodies) in developing B and T-lymphocytes. The V stands for variable, D, diversity and J joining. RAG1 functions as the catalytic component while RAG2, although not catalytic, is required for RAG1 to function.
== Disease ==
== Disease ==



Revision as of 22:07, 24 February 2021

Rag1-Rag2-DNA Strand Transfer ComplexRag1-Rag2-DNA Strand Transfer Complex

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You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.

Function

RAG1 and RAG2 form the RAG Complex, which is responsible for regulating the DNA cleavage phase during recombination. V(D)J recombination functions to produce a plethora of immune molecules (antibodies) in developing B and T-lymphocytes. The V stands for variable, D, diversity and J joining. RAG1 functions as the catalytic component while RAG2, although not catalytic, is required for RAG1 to function.

Disease

Relevance

Structural highlights

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ReferencesReferences

  1. Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

James Nolan, Student