2ery: Difference between revisions

<table><tr><td colspan='2'>[[2ery]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ERY FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RRAS2, TC21 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

[[https://www.uniprot.org/uniprot/RRAS2_HUMAN RRAS2_HUMAN]] Defects in RRAS2 are a cause of susceptibility to ovarian cancer (OC) [MIM:[https://omim.org/entry/167000 167000]]. The term ovarian cancer defines common malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.  

[[https://www.uniprot.org/uniprot/RRAS2_HUMAN RRAS2_HUMAN]] It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion.  

[[Category: Human]]

[[Category: Arrowsmith, C]]

[[Category: Burgess, N]]

[[Category: Delft, F von]]

[[Category: Doyle, D]]

[[Category: Edwards, A]]

[[Category: Elkins, J]]

[[Category: Gileadi, C]]

[[Category: Gileadi, O]]

[[Category: Papagrigoriou, E]]

[[Category: Structural genomic]]

[[Category: Salah, E]]

[[Category: Schoch, G]]

[[Category: Soundararajan, M]]

[[Category: Sundstrom, M]]

[[Category: Turnbull, A]]

[[Category: Weigelt, J]]

[[Category: Gdp/gtp binding]]

[[Category: Signaling protein]]