2edx: Difference between revisions

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==Solution structures of the fn3 domain of human receptor-type tyrosine-protein phosphatase F==
==Solution structures of the fn3 domain of human receptor-type tyrosine-protein phosphatase F==
<StructureSection load='2edx' size='340' side='right'caption='[[2edx]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2edx' size='340' side='right'caption='[[2edx]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2edx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EDX FirstGlance]. <br>
<table><tr><td colspan='2'>[[2edx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EDX FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPRF ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2edx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2edx OCA], [https://pdbe.org/2edx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2edx RCSB], [https://www.ebi.ac.uk/pdbsum/2edx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2edx ProSAT], [https://www.topsan.org/Proteins/RSGI/2edx TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2edx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2edx OCA], [https://pdbe.org/2edx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2edx RCSB], [https://www.ebi.ac.uk/pdbsum/2edx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2edx ProSAT], [https://www.topsan.org/Proteins/RSGI/2edx TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/PTPRF_HUMAN PTPRF_HUMAN]] Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase).<ref>PMID:10338209</ref>  The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.<ref>PMID:10338209</ref>
[https://www.uniprot.org/uniprot/PTPRF_HUMAN PTPRF_HUMAN] Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase).<ref>PMID:10338209</ref>  The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.<ref>PMID:10338209</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Inoue M]]
[[Category: Inoue, M]]
[[Category: Kigawa T]]
[[Category: Kigawa, T]]
[[Category: Koshiba S]]
[[Category: Koshiba, S]]
[[Category: Sato M]]
[[Category: Structural genomic]]
[[Category: Yokoyama S]]
[[Category: Sato, M]]
[[Category: Yokoyama, S]]
[[Category: Ec 3 1.3 48]]
[[Category: Lar protein]]
[[Category: Leukocyte antigen related]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rsgi]]
[[Category: Signaling protein]]

Latest revision as of 21:50, 29 May 2024

Solution structures of the fn3 domain of human receptor-type tyrosine-protein phosphatase FSolution structures of the fn3 domain of human receptor-type tyrosine-protein phosphatase F

Structural highlights

2edx is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

PTPRF_HUMAN Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase).[1] The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Nam HJ, Poy F, Krueger NX, Saito H, Frederick CA. Crystal structure of the tandem phosphatase domains of RPTP LAR. Cell. 1999 May 14;97(4):449-57. PMID:10338209
  2. ↑ Nam HJ, Poy F, Krueger NX, Saito H, Frederick CA. Crystal structure of the tandem phosphatase domains of RPTP LAR. Cell. 1999 May 14;97(4):449-57. PMID:10338209
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