1doa: Difference between revisions

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-[[Image:1doa.gif|left|200px]]
+{{Seed}}
+[[Image:1doa.png|left|200px]]
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 {{STRUCTURE_1doa|  PDB=1doa  |  SCENE=  }}
-'''STRUCTURE OF THE RHO FAMILY GTP-BINDING PROTEIN CDC42 IN COMPLEX WITH THE MULTIFUNCTIONAL REGULATOR RHOGDI'''
+===STRUCTURE OF THE RHO FAMILY GTP-BINDING PROTEIN CDC42 IN COMPLEX WITH THE MULTIFUNCTIONAL REGULATOR RHOGDI===
-==Overview==
+<!--
-The RhoGDI proteins serve as key multifunctional regulators of Rho family GTP-binding proteins. The 2.6 A X-ray crystallographic structure of the Cdc42/RhoGDI complex reveals two important sites of interaction between GDI and Cdc42. First, the amino-terminal regulatory arm of the GDI binds to the switch I and II domains of Cdc42 leading to the inhibition of both GDP dissociation and GTP hydrolysis. Second, the geranylgeranyl moiety of Cdc42 inserts into a hydrophobic pocket within the immunoglobulin-like domain of the GDI molecule leading to membrane release. The structural data demonstrate how GDIs serve as negative regulators of small GTP-binding proteins and how the isoprenoid moiety is utilized in this critical regulatory interaction.
+The line below this paragraph, {{ABSTRACT_PUBMED_10676816}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10676816 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10676816}}
 ==About this Structure==
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 [[Category: Rhogdi]]
 [[Category: X-ray]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 14:04:45 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:22:12 2008''