2d9w: Difference between revisions

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==Solution structure of the PH domain of Docking protein 2 from human==
==Solution structure of the PH domain of Docking protein 2 from human==
<StructureSection load='2d9w' size='340' side='right'caption='[[2d9w]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2d9w' size='340' side='right'caption='[[2d9w]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2d9w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D9W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D9W FirstGlance]. <br>
<table><tr><td colspan='2'>[[2d9w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D9W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D9W FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DOK2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d9w OCA], [https://pdbe.org/2d9w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d9w RCSB], [https://www.ebi.ac.uk/pdbsum/2d9w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d9w ProSAT], [https://www.topsan.org/Proteins/RSGI/2d9w TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d9w OCA], [https://pdbe.org/2d9w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d9w RCSB], [https://www.ebi.ac.uk/pdbsum/2d9w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d9w ProSAT], [https://www.topsan.org/Proteins/RSGI/2d9w TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/DOK2_HUMAN DOK2_HUMAN]] DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity).  
[https://www.uniprot.org/uniprot/DOK2_HUMAN DOK2_HUMAN] DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Inoue, M]]
[[Category: Inoue M]]
[[Category: Kigawa, T]]
[[Category: Kigawa T]]
[[Category: Koshiba, S]]
[[Category: Koshiba S]]
[[Category: Li, H]]
[[Category: Li H]]
[[Category: Structural genomic]]
[[Category: Tomizawa T]]
[[Category: Tomizawa, T]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S]]
[[Category: Docking protein 2]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Ph domain]]
[[Category: Rsgi]]
[[Category: Signaling protein]]

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