2azv: Difference between revisions

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 ==Solution structure of the T22G mutant of N-terminal SH3 domain of DRK (calculated without NOEs)==
-<StructureSection load='2azv' size='340' side='right'caption='[[2azv]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
+<StructureSection load='2azv' size='340' side='right'caption='[[2azv]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2azv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AZV FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2azv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AZV FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2a37|2a37]], [[2a36|2a36]], [[2azs|2azs]]</div></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">drk, E sev 2B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2azv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2azv OCA], [https://pdbe.org/2azv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2azv RCSB], [https://www.ebi.ac.uk/pdbsum/2azv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2azv ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/DRK_DROME DRK_DROME]] Required for proper signaling by sevenless. May act to stimulate the ability of Sos to catalyze Ras1 activation by linking sevenless and Sos in a signaling complex.<ref>PMID:8462097</ref> <ref>PMID:8462098</ref>
+[https://www.uniprot.org/uniprot/GRAP_DROME GRAP_DROME] Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as sev and Ack (PubMed:8462097, PubMed:22615583, PubMed:8462098). Required for proper signaling by sevenless (PubMed:8462097, PubMed:8462098). May act to stimulate the ability of Sos to catalyze Ras1 activation by linking sevenless and Sos in a signaling complex (PubMed:8462097, PubMed:8462098). Required for functional and morphological integrities of the scolopidia, sensory neurons and the antennal mechanosensory and motor center (AMMC) brain neuropil (PubMed:30610177). Required for Ack-dependent suppression of apoptosis in the eye (PubMed:22615583).<ref>PMID:22615583</ref> <ref>PMID:30610177</ref> <ref>PMID:8462097</ref> <ref>PMID:8462098</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
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 __TOC__
 </StructureSection>
-[[Category: Drome]]
+[[Category: Drosophila melanogaster]]
 [[Category: Large Structures]]
-[[Category: Bezsonova, I]]
+[[Category: Bezsonova I]]
-[[Category: Choy, W Y]]
+[[Category: Choy W-Y]]
-[[Category: Forman-Kay, J D]]
+[[Category: Forman-Kay JD]]
-[[Category: Singer, A U]]
+[[Category: Singer AU]]
-[[Category: Tollinger, M]]
+[[Category: Tollinger M]]
-[[Category: Beta-barrel]]
-[[Category: Signaling protein]]