2adb: Difference between revisions
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==Solution structure of Polypyrimidine Tract Binding protein RBD2 complexed with CUCUCU RNA== | ==Solution structure of Polypyrimidine Tract Binding protein RBD2 complexed with CUCUCU RNA== | ||
<StructureSection load='2adb' size='340' side='right'caption='[[2adb | <StructureSection load='2adb' size='340' side='right'caption='[[2adb]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2adb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2adb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ADB FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2adb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adb OCA], [https://pdbe.org/2adb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2adb RCSB], [https://www.ebi.ac.uk/pdbsum/2adb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2adb ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2adb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adb OCA], [https://pdbe.org/2adb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2adb RCSB], [https://www.ebi.ac.uk/pdbsum/2adb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2adb ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/PTBP1_HUMAN PTBP1_HUMAN] Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:11003644</ref> <ref>PMID:15009664</ref> <ref>PMID:16260624</ref> <ref>PMID:21518792</ref> <ref>PMID:16179478</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Allain | [[Category: Allain FHT]] | ||
[[Category: Auweter | [[Category: Auweter SD]] | ||
[[Category: Black | [[Category: Black DL]] | ||
[[Category: Erat | [[Category: Erat M]] | ||
[[Category: Hargous | [[Category: Hargous Y]] | ||
[[Category: Henning | [[Category: Henning A]] | ||
[[Category: Oberstrass | [[Category: Oberstrass FC]] | ||
[[Category: Pitsch | [[Category: Pitsch S]] | ||
[[Category: Reymond | [[Category: Reymond L]] | ||
[[Category: Wenter | [[Category: Wenter P]] | ||