Nuclear receptors: Difference between revisions

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-<StructureSection load='' size='350' side='right' caption='' scene='83/831988/Cv/2'>
+<StructureSection load='' size='340' side='right' caption='Human androgen receptor ligand-binding domain complex with modulator (PDB code [[3b5r]])' scene='54/543362/Cv/1'>
 '''Under development!!!'''
+AR structure is composed of 5 domains - <br />
+A/B: N-terminal regulatory domain contains activation function 1 (residues 101-370),  activation function 5 (residues 360-485) and dimerization surface (residues 1-36 and 370-494).<br />
+C: DNA binding domain (DBD)<br />
+D: Hinge region between DBD and LBD<br />
+E: Ligand binding domain (LBD) containing an <scene name='54/543362/Cv/3'>active site</scene> which binds intramolecularly the N-terminal FXXFL motif or coactivators with the same motif.<ref>PMID:18805694</ref> Water molecules are shown as red spheres. <br />
+F: C-terminal domain
 = '''Estrogen Receptor-like'''=