1yla: Difference between revisions

<table><tr><td colspan='2'>[[1yla]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YLA FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yla OCA], [https://pdbe.org/1yla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yla RCSB], [https://www.ebi.ac.uk/pdbsum/1yla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yla ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/UBE2K_HUMAN UBE2K_HUMAN] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.<ref>PMID:8702625</ref> <ref>PMID:10634809</ref> <ref>PMID:10675012</ref> <ref>PMID:16714285</ref> <ref>PMID:16868077</ref> <ref>PMID:17873885</ref> <ref>PMID:20061386</ref> <ref>PMID:19906396</ref>  

*[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]]

[[Category: Homo sapiens]]

[[Category: Arrowsmith C]]

[[Category: Avvakumov GV]]

[[Category: Bochkarev A]]

[[Category: Choe J]]

[[Category: Dhe-paganon S]]

[[Category: Edwards A]]

[[Category: Kozieradzki I]]

[[Category: Mackenzie F]]

[[Category: Newman EM]]

[[Category: Sundstrom M]]