1diy: Difference between revisions

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-[[Image:1diy.gif|left|200px]]
+{{Seed}}
+[[Image:1diy.png|left|200px]]
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 {{STRUCTURE_1diy|  PDB=1diy  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND IN THE CYCLOOXYGENASE ACTIVE SITE OF PGHS-1'''
+===CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND IN THE CYCLOOXYGENASE ACTIVE SITE OF PGHS-1===
-==Overview==
+<!--
-Prostaglandin H synthase-1 and -2 (PGHS-1 and -2) catalyze the committed step in prostaglandin synthesis and are targets for nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin. We have determined the structure of PGHS-1 at 3 angstrom resolution with arachidonic acid (AA) bound in a chemically productive conformation. The fatty acid adopts an extended L-shaped conformation that positions the 13proS hydrogen of AA for abstraction by tyrosine-385, the likely radical donor. A space also exists for oxygen addition on the antarafacial surface of the carbon in the 11-position (C-11). While this conformation allows endoperoxide formation between C-11 and C-9, it also implies that a subsequent conformational rearrangement must occur to allow formation of the C-8/C-12 bond and to position C-15 for attack by a second molecule of oxygen.
+The line below this paragraph, {{ABSTRACT_PUBMED_10988074}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10988074 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10988074}}
 ==About this Structure==
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 [[Category: Membrane protein]]
 [[Category: Peroxidase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:54:00 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:08:04 2008''