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==Crystal structure of MurE from E.coli in complex with Z1269139261== | ==Crystal structure of MurE from E.coli in complex with Z1269139261== | ||
<StructureSection load='7b60' size='340' side='right'caption='[[7b60]]' scene=''> | <StructureSection load='7b60' size='340' side='right'caption='[[7b60]], [[Resolution|resolution]] 1.91Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B60 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7B60 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7b60]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B60 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7B60 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7b60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b60 OCA], [http://pdbe.org/7b60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7b60 RCSB], [http://www.ebi.ac.uk/pdbsum/7b60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7b60 ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=O3D:4-[(furan-2-yl)methyl]-1lambda~6~,4-thiazinane-1,1-dione'>O3D</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate_ligase UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.13 6.3.2.13] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7b60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b60 OCA], [http://pdbe.org/7b60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7b60 RCSB], [http://www.ebi.ac.uk/pdbsum/7b60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7b60 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/MURE_ECOLI MURE_ECOLI]] Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine.<ref>PMID:2269304</ref> <ref>PMID:3905407</ref> <ref>PMID:11124264</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase]] | ||
[[Category: Bountra C]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Edwards | [[Category: Bountra, C]] | ||
[[Category: Fairhead M]] | [[Category: Delft, F von]] | ||
[[Category: Koekemoer L]] | [[Category: Douangamath, A]] | ||
[[Category: Krojer T]] | [[Category: Edwards, A M]] | ||
[[Category: Steindel M]] | [[Category: Fairhead, M]] | ||
[[Category: | [[Category: Koekemoer, L]] | ||
[[Category: Krojer, T]] | |||
[[Category: Structural genomic]] | |||
[[Category: Steindel, M]] | |||
[[Category: Talon, R]] | |||
[[Category: 6-diaminopimelate ligase cell wall biosynthesis ligase]] | |||
[[Category: Biosynthetic protein]] | |||
[[Category: Drug target]] | |||
[[Category: Fragment screening]] | |||
[[Category: Sgc]] | |||
[[Category: Udp-n-acetylmuramoyl-l-alanyl-d-glutamate-2]] | |||
Revision as of 10:03, 30 December 2020
Crystal structure of MurE from E.coli in complex with Z1269139261Crystal structure of MurE from E.coli in complex with Z1269139261
Structural highlights
Function[MURE_ECOLI] Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine.[1] [2] [3] References
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Large Structures
- UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
- Arrowsmith, C H
- Bountra, C
- Delft, F von
- Douangamath, A
- Edwards, A M
- Fairhead, M
- Koekemoer, L
- Krojer, T
- Structural genomic
- Steindel, M
- Talon, R
- 6-diaminopimelate ligase cell wall biosynthesis ligase
- Biosynthetic protein
- Drug target
- Fragment screening
- Sgc
- Udp-n-acetylmuramoyl-l-alanyl-d-glutamate-2