1nl9: Difference between revisions

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 <StructureSection load='1nl9' size='340' side='right'caption='[[1nl9]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1nl9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NL9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1NL9 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1nl9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NL9 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=989:2-{[4-(2-ACETYLAMINO-2-PENTYLCARBAMOYL-ETHYL)-NAPHTHALEN-1-YL]-OXALYL-AMINO}-BENZOIC+ACID'>989</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1nny|1nny]], [[1no6|1no6]]</div></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=989:2-{[4-(2-ACETYLAMINO-2-PENTYLCARBAMOYL-ETHYL)-NAPHTHALEN-1-YL]-OXALYL-AMINO}-BENZOIC+ACID'>989</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPN1 OR PTP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nl9 OCA], [https://pdbe.org/1nl9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nl9 RCSB], [https://www.ebi.ac.uk/pdbsum/1nl9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nl9 ProSAT]</span></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1nl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nl9 OCA], [http://pdbe.org/1nl9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nl9 RCSB], [http://www.ebi.ac.uk/pdbsum/1nl9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1nl9 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
+[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 38: / Line 36: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Protein-tyrosine-phosphatase]]
+[[Category: Abad-Zapatero C]]
-[[Category: Abad-Zapatero, C]]
+[[Category: Ballaron SJ]]
-[[Category: Ballaron, S J]]
+[[Category: Fesik SW]]
-[[Category: Fesik, S W]]
+[[Category: Hajduk PJ]]
-[[Category: Hajduk, P J]]
+[[Category: Huang F]]
-[[Category: Huang, F]]
+[[Category: Hutchins CW]]
-[[Category: Hutchins, C W]]
+[[Category: Jirousek MR]]
-[[Category: Jirousek, M R]]
+[[Category: Liang H]]
-[[Category: Liang, H]]
+[[Category: Liu G]]
-[[Category: Liu, G]]
+[[Category: Lubben T]]
-[[Category: Lubben, T]]
+[[Category: Pei Z]]
-[[Category: Pei, Z]]
+[[Category: Stashko MA]]
-[[Category: Stashko, M A]]
+[[Category: Szczepankiewicz BG]]
-[[Category: Szczepankiewicz, B G]]
+[[Category: Trevillyan JM]]
-[[Category: Trevillyan, J M]]
+[[Category: Xin Z]]
-[[Category: Xin, Z]]
-[[Category: Dual-site oxamic acid inhibitor bound to p-loop]]
-[[Category: Hydrolase]]
-[[Category: Protein tyrosine phosphatase fold]]