1d7j: Difference between revisions

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OCA

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-[[Image:1d7j.gif|left|200px]]
+{{Seed}}
+[[Image:1d7j.png|left|200px]]
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 {{STRUCTURE_1d7j|  PDB=1d7j  |  SCENE=  }}
-'''FKBP COMPLEXED WITH 4-HYDROXY-2-BUTANONE'''
+===FKBP COMPLEXED WITH 4-HYDROXY-2-BUTANONE===
-==Overview==
+<!--
-A new crystal form of native FK506 binding protein (FKBP) has been obtained which has proved useful in ligand binding studies. Three different small molecule ligand complexes and the native enzyme have been determined at higher resolution than 2.0 A. Dissociation constants of the related small molecule ligands vary from 20 mM for dimethylsulphoxide to 200 microM for tetrahydrothiophene 1-oxide. Comparison of the four available crystal structures shows that the protein structures are identical to within experimental error, but there are differences in the water structure in the active site. Analysis of the calculated buried surface areas of these related ligands provides an estimated van der Waals contribution to the binding energy of -0.5 kJ/A(2) for non-polar interactions between ligand and protein.
+The line below this paragraph, {{ABSTRACT_PUBMED_10656803}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10656803 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10656803}}
 ==About this Structure==
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 [[Category: Immunophilin]]
 [[Category: Isomerase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:32:03 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:37:27 2008''