1lo1: Difference between revisions

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<StructureSection load='1lo1' size='340' side='right'caption='[[1lo1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1lo1' size='340' side='right'caption='[[1lo1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1lo1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1LO1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1lo1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LO1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hERR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hERR2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1lo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo1 OCA], [http://pdbe.org/1lo1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lo1 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lo1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo1 OCA], [https://pdbe.org/1lo1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lo1 RCSB], [https://www.ebi.ac.uk/pdbsum/1lo1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lo1 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/ERR2_HUMAN ERR2_HUMAN]] Defects in ESRRB are the cause of deafness autosomal recessive type 35 (DFNB35) [MIM:[http://omim.org/entry/608565 608565]]. DFNB35 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:18179891</ref>   
[[https://www.uniprot.org/uniprot/ERR2_HUMAN ERR2_HUMAN]] Defects in ESRRB are the cause of deafness autosomal recessive type 35 (DFNB35) [MIM:[https://omim.org/entry/608565 608565]]. DFNB35 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:18179891</ref>   
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ERR2_HUMAN ERR2_HUMAN]] Nuclear receptor, may regulate ESR1 transcriptional activity.<ref>PMID:19755138</ref>   
[[https://www.uniprot.org/uniprot/ERR2_HUMAN ERR2_HUMAN]] Nuclear receptor, may regulate ESR1 transcriptional activity.<ref>PMID:19755138</ref>   
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

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