6zfx: Difference between revisions
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<StructureSection load='6zfx' size='340' side='right'caption='[[6zfx]], [[Resolution|resolution]] 2.88Å' scene=''> | <StructureSection load='6zfx' size='340' side='right'caption='[[6zfx]], [[Resolution|resolution]] 2.88Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6zfx]] is a 8 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6zfx]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZFX FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=S1N:(~{E})-4-methylnon-4-enedial'>S1N</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=S1N:(~{E})-4-methylnon-4-enedial'>S1N</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zfx OCA], [https://pdbe.org/6zfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zfx RCSB], [https://www.ebi.ac.uk/pdbsum/6zfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zfx ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/SARM1_HUMAN SARM1_HUMAN] Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.<ref>PMID:15123841</ref> <ref>PMID:16964262</ref> <ref>PMID:16985498</ref> <ref>PMID:20306472</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 6zfx" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6zfx" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[SARM1 3D structures|SARM1 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Dessau | [[Category: Dessau M]] | ||
[[Category: Guez-Haddad | [[Category: Guez-Haddad J]] | ||
[[Category: Hons | [[Category: Hons M]] | ||
[[Category: Isupov | [[Category: Isupov MN]] | ||
[[Category: Khazma | [[Category: Khazma T]] | ||
[[Category: Mim | [[Category: Mim C]] | ||
[[Category: Opatowsky | [[Category: Opatowsky Y]] | ||
[[Category: Sporny | [[Category: Sporny M]] | ||
[[Category: Yaron | [[Category: Yaron A]] | ||
[[Category: Zalk | [[Category: Zalk R]] | ||