6yel: Difference between revisions

<StructureSection load='6yel' size='340' side='right'caption='[[6yel]]' scene=''>

<table><tr><td colspan='2'>[[6yel]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YEL FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yel OCA], [https://pdbe.org/6yel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yel RCSB], [https://www.ebi.ac.uk/pdbsum/6yel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yel ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/STIM1_HUMAN STIM1_HUMAN] Defects in STIM1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 2 (IDTICED2) [MIM:[https://omim.org/entry/612783 612783]. IDTICED2 is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, lymphadenopathy, and normal lymphocytes counts and serum immunoglobulin levels. Additional features include thrombocytopenia, autoimmune hemolytic anemia, non-progressive myopathy, partial iris hypoplasia, hepatosplenomegaly and defective enamel dentition.<ref>PMID:19420366</ref>  

[https://www.uniprot.org/uniprot/STIM1_HUMAN STIM1_HUMAN] Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.<ref>PMID:9377559</ref> <ref>PMID:16005298</ref> <ref>PMID:15866891</ref> <ref>PMID:16208375</ref> <ref>PMID:16807233</ref> <ref>PMID:16766533</ref> <ref>PMID:16733527</ref> <ref>PMID:16537481</ref> <ref>PMID:22464749</ref>  

[[Category: Homo sapiens]]

[[Category: Bechmann M]]

[[Category: Cerofolini L]]

[[Category: Fahrner M]]

[[Category: Fragai M]]

[[Category: Grabmayr H]]

[[Category: Luchinat C]]

[[Category: Mueller N]]

[[Category: Rathner P]]

[[Category: Ravera E]]

[[Category: Romanin C]]