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==Neuraminidase from the Wuhan Asiatic toad influenza virus== | ==Neuraminidase from the Wuhan Asiatic toad influenza virus== | ||
<StructureSection load='7cm1' size='340' side='right'caption='[[7cm1]]' scene=''> | <StructureSection load='7cm1' size='340' side='right'caption='[[7cm1]], [[Resolution|resolution]] 2.14Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CM1 OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[7cm1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Wuhan_asiatic_toad_influenza_virus Wuhan asiatic toad influenza virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CM1 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.14Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=G39:(3R,4R,5S)-4-(ACETYLAMINO)-5-AMINO-3-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>G39</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cm1 OCA], [https://pdbe.org/7cm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cm1 RCSB], [https://www.ebi.ac.uk/pdbsum/7cm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cm1 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A2P1GNT2_9ORTO A0A2P1GNT2_9ORTO] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Neuraminidase (NA) inhibitors are one of the two major classes of antivirals available for the treatment and prevention of influenza. X-ray crystal structure determination of NA head domains and their complexes with various inhibitors are of importance for the design and optimization of anti-influenza drugs. However, the globular tetrameric properties of NA head domains may produce crystals with pathological imperfections, lattice-translocation defects, making structure determination no longer straightforward. In this report, using a crystal of the NA head domain from the Wuhan Asiatic toad influenza virus as an example, the identification and solution of this type of crystal pathology are presented. Furthermore, its underlying mechanism of formation is explored. | |||
Lattice-translocation defects in specific crystals of the catalytic head domain of influenza neuraminidase.,Li L, Dai S, Gao GF, Wang J Acta Crystallogr D Struct Biol. 2020 Nov 1;76(Pt 11):1057-1064. doi:, 10.1107/S2059798320011869. Epub 2020 Oct 13. PMID:33135677<ref>PMID:33135677</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7cm1" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Neuraminidase 3D structures|Neuraminidase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Wuhan asiatic toad influenza virus]] | |||
[[Category: Wang J]] | [[Category: Wang J]] | ||
Revision as of 19:10, 29 November 2023
Neuraminidase from the Wuhan Asiatic toad influenza virusNeuraminidase from the Wuhan Asiatic toad influenza virus
Structural highlights
FunctionA0A2P1GNT2_9ORTO Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.[RuleBase:RU361252] Publication Abstract from PubMedNeuraminidase (NA) inhibitors are one of the two major classes of antivirals available for the treatment and prevention of influenza. X-ray crystal structure determination of NA head domains and their complexes with various inhibitors are of importance for the design and optimization of anti-influenza drugs. However, the globular tetrameric properties of NA head domains may produce crystals with pathological imperfections, lattice-translocation defects, making structure determination no longer straightforward. In this report, using a crystal of the NA head domain from the Wuhan Asiatic toad influenza virus as an example, the identification and solution of this type of crystal pathology are presented. Furthermore, its underlying mechanism of formation is explored. Lattice-translocation defects in specific crystals of the catalytic head domain of influenza neuraminidase.,Li L, Dai S, Gao GF, Wang J Acta Crystallogr D Struct Biol. 2020 Nov 1;76(Pt 11):1057-1064. doi:, 10.1107/S2059798320011869. Epub 2020 Oct 13. PMID:33135677[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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