Sandbox GGC7: Difference between revisions
No edit summary |
No edit summary |
||
| Line 5: | Line 5: | ||
The insulin-degrading enzyme (IDE) is a highly conserved protease that uses <scene name='75/752270/Ide_with_insulin_b/2'>zinc (Zn2+)</scene> as a cofactor in breaking down insulin and amyloid beta-proteins <ref>doi: 10.1038/nature05143</ref>. IDE can be found predominantly in the cytosol, however it is also located in the cell membrane, secreted into the extracellular regions and is present at the cell surfaces of neuron cells in the brain. Insulin-degrading enzyme is also known as insulysin or insulinase and is active at neutral pH. It can be located in red blood cells, skeletal muscle, liver and brain. | The insulin-degrading enzyme (IDE) is a highly conserved protease that uses <scene name='75/752270/Ide_with_insulin_b/2'>zinc (Zn2+)</scene> as a cofactor in breaking down insulin and amyloid beta-proteins <ref>doi: 10.1038/nature05143</ref>. IDE can be found predominantly in the cytosol, however it is also located in the cell membrane, secreted into the extracellular regions and is present at the cell surfaces of neuron cells in the brain. Insulin-degrading enzyme is also known as insulysin or insulinase and is active at neutral pH. It can be located in red blood cells, skeletal muscle, liver and brain. | ||
== Structure == | == Structure == | ||