1czq: Difference between revisions

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-[[Image:1czq.gif|left|200px]]
+{{Seed}}
+[[Image:1czq.png|left|200px]]
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 {{STRUCTURE_1czq|  PDB=1czq  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF THE D10-P1/IQN17 COMPLEX: A D-PEPTIDE INHIBITOR OF HIV-1 ENTRY BOUND TO THE GP41 COILED-COIL POCKET.'''
+===CRYSTAL STRUCTURE OF THE D10-P1/IQN17 COMPLEX: A D-PEPTIDE INHIBITOR OF HIV-1 ENTRY BOUND TO THE GP41 COILED-COIL POCKET.===
-==Overview==
+<!--
-The HIV-1 gp41 protein promotes viral entry by mediating the fusion of viral and cellular membranes. A prominent pocket on the surface of a central trimeric coiled coil within gp41 was previously identified as a potential target for drugs that inhibit HIV-1 entry. We designed a peptide, IQN17, which properly presents this pocket. Utilizing IQN17 and mirror-image phage display, we identified cyclic, D-peptide inhibitors of HIV-1 infection that share a sequence motif. A 1.5 A cocrystal structure of IQN17 in complex with a D-peptide, and NMR studies, show that conserved residues of these inhibitors make intimate contact with the gp41 pocket. Our studies validate the pocket per se as a target for drug development. IQN17 and these D-peptide inhibitors are likely to be useful for development and identification of a new class of orally bioavailable anti-HIV drugs.
+The line below this paragraph, {{ABSTRACT_PUBMED_10520998}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10520998 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10520998}}
 ==About this Structure==
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 [[Category: Coiled coil]]
 [[Category: Envelope glycoprotein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:17:01 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 21:53:17 2008''