1cx0: Difference between revisions

Revision as of 21:41, 30 June 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1cx0.png

Template:STRUCTURE 1cx0

HEPATITIS DELTA VIRUS RIBOZYMEHEPATITIS DELTA VIRUS RIBOZYME

Template:ABSTRACT PUBMED 9783582

About this StructureAbout this Structure

1CX0 is a Single protein structure of sequence from Hepatitis delta virus. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of a hepatitis delta virus ribozyme., Ferre-D'Amare AR, Zhou K, Doudna JA, Nature. 1998 Oct 8;395(6702):567-74. PMID:9783582

Page seeded by OCA on Mon Jun 30 21:40:54 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''HEPATITIS DELTA VIRUS RIBOZYME'''
+===HEPATITIS DELTA VIRUS RIBOZYME===
-==Overview==
+<!--
-The self-cleaving ribozyme of the hepatitis delta virus (HDV) is the only catalytic RNA known to be required for the viability of a human pathogen. We obtained crystals of a 72-nucleotide, self-cleaved form of the genomic HDV ribozyme that diffract X-rays to 2.3 A resolution by engineering the RNA to bind a small, basic protein without affecting ribozyme activity. The co-crystal structure shows that the compact catalytic core comprises five helical segments connected as an intricate nested double pseudoknot. The 5'-hydroxyl leaving group resulting from the self-scission reaction is buried deep within an active-site cleft produced by juxtaposition of the helices and five strand-crossovers, and is surrounded by biochemically important backbone and base functional groups in a manner reminiscent of protein enzymes.
+The line below this paragraph, {{ABSTRACT_PUBMED_9783582}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9783582 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_9783582}}
 ==About this Structure==
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 [[Category: Zhou, K.]]
 [[Category: Nested double pseudoknot rna structure]]
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