1cwv: Difference between revisions

Revision as of 21:40, 30 June 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:1cwv.png

Template:STRUCTURE 1cwv

CRYSTAL STRUCTURE OF INVASIN: A BACTERIAL INTEGRIN-BINDING PROTEINCRYSTAL STRUCTURE OF INVASIN: A BACTERIAL INTEGRIN-BINDING PROTEIN

Template:ABSTRACT PUBMED 10514372

About this StructureAbout this Structure

1CWV is a Single protein structure of sequence from Yersinia pseudotuberculosis. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of invasin: a bacterial integrin-binding protein., Hamburger ZA, Brown MS, Isberg RR, Bjorkman PJ, Science. 1999 Oct 8;286(5438):291-5. PMID:10514372

Page seeded by OCA on Mon Jun 30 21:40:12 2008

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-'''CRYSTAL STRUCTURE OF INVASIN: A BACTERIAL INTEGRIN-BINDING PROTEIN'''
+===CRYSTAL STRUCTURE OF INVASIN: A BACTERIAL INTEGRIN-BINDING PROTEIN===
-==Overview==
+<!--
-The Yersinia pseudotuberculosis invasin protein promotes bacterial entry by binding to host cell integrins with higher affinity than natural substrates such as fibronectin. The 2.3 angstrom crystal structure of the invasin extracellular region reveals five domains that form a 180 angstrom rod with structural similarities to tandem fibronectin type III domains. The integrin-binding surfaces of invasin and fibronectin include similarly located key residues, but in the context of different folds and surface shapes. The structures of invasin and fibronectin provide an example of convergent evolution, in which invasin presents an optimized surface for integrin binding, in comparison with host substrates.
+The line below this paragraph, {{ABSTRACT_PUBMED_10514372}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_10514372}}
 ==About this Structure==
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 [[Category: Integrin-binding protein]]
 [[Category: Inv gene]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:12:00 2008''
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