5xpy: Difference between revisions

<table><tr><td colspan='2'>[[5xpy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XPY FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.099&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xpy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xpy OCA], [https://pdbe.org/5xpy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xpy RCSB], [https://www.ebi.ac.uk/pdbsum/5xpy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xpy ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/FERM2_MOUSE FERM2_MOUSE] Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.<ref>PMID:18174465</ref> <ref>PMID:18483218</ref> <ref>PMID:21378273</ref>  

[[Category: Li H]]

[[Category: Sun K]]

[[Category: Wei Z]]

[[Category: Yang H]]

[[Category: Yu C]]

[[Category: Zhang Z]]