5vr7: Difference between revisions

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<StructureSection load='5vr7' size='340' side='right'caption='[[5vr7]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
<StructureSection load='5vr7' size='340' side='right'caption='[[5vr7]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5vr7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VR7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5VR7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5vr7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VR7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1F:1-(2-fluoro-4-methylphenyl)-N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)methanesulfonamide'>A1F</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.612&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vsr|5vsr]], [[5vro|5vro]], [[5vsq|5vsq]], [[5vs5|5vs5]], [[5vt7|5vt7]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1F:1-(2-fluoro-4-methylphenyl)-N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)methanesulfonamide'>A1F</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vr7 OCA], [https://pdbe.org/5vr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vr7 RCSB], [https://www.ebi.ac.uk/pdbsum/5vr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vr7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5vr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vr7 OCA], [http://pdbe.org/5vr7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vr7 RCSB], [http://www.ebi.ac.uk/pdbsum/5vr7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vr7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref>  [[http://www.uniprot.org/uniprot/P2C16_ARATH P2C16_ARATH]] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought.<ref>PMID:14731256</ref> <ref>PMID:16876791</ref> <ref>PMID:16798945</ref> <ref>PMID:19033529</ref> 
[https://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref>  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Drought stress is a major threat to crop production, but effective methods to mitigate the adverse effects of drought are not available. Here, we report that adding fluorine atoms in the benzyl ring of the abscisic acid (ABA) receptor agonist AM1 optimizes its binding to ABA receptors by increasing the number of hydrogen bonds between the compound and the surrounding amino acid residues in the receptor ligand-binding pocket. The new chemicals, known as AMFs, have long-lasting effects in promoting stomatal closure and inducing the expression of stress-responsive genes. Application of AMFs or transgenic overexpression of the receptor PYL2 in Arabidopsis and soybean plants confers increased drought resistance. The greatest increase in drought resistance is achieved when AMFs are applied to the PYL2-overexpression transgenic plants. Our results demonstrate that the combining of potent chemicals with transgenic overexpression of an ABA receptor is very effective in helping plants combat drought stress.
 
Combining chemical and genetic approaches to increase drought resistance in plants.,Cao MJ, Zhang YL, Liu X, Huang H, Zhou XE, Wang WL, Zeng A, Zhao CZ, Si T, Du J, Wu WW, Wang FX, Xu HE, Zhu JK Nat Commun. 2017 Oct 30;8(1):1183. doi: 10.1038/s41467-017-01239-3. PMID:29084945<ref>PMID:29084945</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5vr7" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Abscisic acid receptor 3D structures|Abscisic acid receptor 3D structures]]
*[[Abscisic acid receptor 3D structures|Abscisic acid receptor 3D structures]]
*[[Protein Phosphatase 2C|Protein Phosphatase 2C]]
*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Phosphoprotein phosphatase]]
[[Category: Cao M-J]]
[[Category: Cao, M J]]
[[Category: Du J-M]]
[[Category: Du, J M]]
[[Category: Huang H]]
[[Category: Huang, H]]
[[Category: Liu X]]
[[Category: Liu, X]]
[[Category: Si T]]
[[Category: Si, T]]
[[Category: Wang F-X]]
[[Category: Wang, F X]]
[[Category: Wang W-L]]
[[Category: Wang, W L]]
[[Category: Wu W-W]]
[[Category: Wu, W W]]
[[Category: Xu HE]]
[[Category: Xu, H E]]
[[Category: Zeng A]]
[[Category: Zeng, A]]
[[Category: Zhang Y-L]]
[[Category: Zhang, Y L]]
[[Category: Zhao C-Z]]
[[Category: Zhao, C Z]]
[[Category: Zhou XE]]
[[Category: Zhou, X E]]
[[Category: Zhu J-K]]
[[Category: Zhu, J K]]
[[Category: Aba]]
[[Category: Agonist]]
[[Category: Amf]]
[[Category: Drought resistance]]
[[Category: Hydrolase]]
[[Category: Receptor]]

Latest revision as of 17:11, 13 March 2024

ABA-mimicking ligand AMF1alpha in complex with ABA receptor PYL2 and PP2C HAB1ABA-mimicking ligand AMF1alpha in complex with ABA receptor PYL2 and PP2C HAB1

Structural highlights

5vr7 is a 2 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.612Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PYL2_ARATH Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.[1] [2]

See Also

References

  1. ↑ Melcher K, Ng LM, Zhou XE, Soon FF, Xu Y, Suino-Powell KM, Park SY, Weiner JJ, Fujii H, Chinnusamy V, Kovach A, Li J, Wang Y, Li J, Peterson FC, Jensen DR, Yong EL, Volkman BF, Cutler SR, Zhu JK, Xu HE. A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors. Nature. 2009 Dec 3;462(7273):602-8. PMID:19898420 doi:10.1038/nature08613
  2. ↑ Yin P, Fan H, Hao Q, Yuan X, Wu D, Pang Y, Yan C, Li W, Wang J, Yan N. Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat Struct Mol Biol. 2009 Dec;16(12):1230-6. Epub 2009 Nov 5. PMID:19893533 doi:10.1038/nsmb.1730

5vr7, resolution 2.61Å

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