1cjm: Difference between revisions

Revision as of 20:50, 30 June 2008

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File:1cjm.png

Template:STRUCTURE 1cjm

HUMAN SULT1A3 WITH SULFATE BOUNDHUMAN SULT1A3 WITH SULFATE BOUND

Template:ABSTRACT PUBMED 10543947

About this StructureAbout this Structure

1CJM is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of human catecholamine sulfotransferase., Bidwell LM, McManus ME, Gaedigk A, Kakuta Y, Negishi M, Pedersen L, Martin JL, J Mol Biol. 1999 Oct 29;293(3):521-30. PMID:10543947

Page seeded by OCA on Mon Jun 30 20:50:14 2008

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OCA

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-'''HUMAN SULT1A3 WITH SULFATE BOUND'''
+===HUMAN SULT1A3 WITH SULFATE BOUND===
-==Overview==
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-Sulfonation, like phosphorylation, can modify the activity of a variety of biological molecules. The sulfotransferase enzymes sulfonate neurotransmitters, drugs, steroid hormones, dietary carcinogens and proteins. SULT1A3 specifically sulfonates catecholamines such as dopamine, adrenaline and noradrenaline. The crystal structure of SULT1A3 with a sulfate bound at the active site, has been determined at 2.4 A resolution. Although the core alpha/beta fold is like that of estrogen and heparan sulfotransferases, major differences occur in and around the active site. Most notably, several regions surrounding the active site, including a section of 40 residues, are disordered in SULT1A3. Regions that are topologically equivalent to the disordered parts of SULT1A3 are involved in substrate and cofactor binding in estrogen and heparan sulfotransferase. Flexibility in these regions suggests that ligand binding elicits a disorder-order transition in and around the active site of sulfotransferases and might contribute to the broad substrate specificity of these enzymes.
+The line below this paragraph, {{ABSTRACT_PUBMED_10543947}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10543947 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_10543947}}
 ==About this Structure==
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 [[Category: Sulfotransferase]]
 [[Category: Sult1a3]]
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