Liver X receptor: Difference between revisions
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'''Liver X receptors''' (LXR) are ligand-activated transcription factors of the nuclear receptor family. There are two LXR isoforms α and β which form heterodimers with retinoic X receptor upon activation and bind to the LXR response element found in the promoter region of the target genes<ref>PMID:19258656</ref>. LXR is a lipogenic transcription factor<ref>PMID:17107947</ref>. LXRs modulate the expression of genes in cholesterol and lipid metabolism in response to changes in cellular cholesterol status. | '''Liver X receptors''' (LXR) are ligand-activated transcription factors of the nuclear receptor family. There are two LXR isoforms α and β which form heterodimers with retinoic X receptor upon activation and bind to the LXR response element found in the promoter region of the target genes<ref>PMID:19258656</ref>. LXR is a lipogenic transcription factor<ref>PMID:17107947</ref>. LXRs modulate the expression of genes in cholesterol and lipid metabolism in response to changes in cellular cholesterol status. | ||
See also [[Intracellular receptors]] | |||
== Disease == | == Disease == | ||