5m7r: Difference between revisions
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<StructureSection load='5m7r' size='340' side='right'caption='[[5m7r]], [[Resolution|resolution]] 2.35Å' scene=''> | <StructureSection load='5m7r' size='340' side='right'caption='[[5m7r]], [[Resolution|resolution]] 2.35Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5m7r]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5m7r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M7R FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m7r OCA], [https://pdbe.org/5m7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m7r RCSB], [https://www.ebi.ac.uk/pdbsum/5m7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m7r ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/OGA_HUMAN OGA_HUMAN] Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).<ref>PMID:11148210</ref> <ref>PMID:11788610</ref> <ref>PMID:20673219</ref> <ref>PMID:22365600</ref> <ref>PMID:24088714</ref> Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.<ref>PMID:20673219</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5m7r" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5m7r" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[O-GlcNAcase|O-GlcNAcase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Britton | [[Category: Britton R]] | ||
[[Category: Chan | [[Category: Chan S]] | ||
[[Category: Davies | [[Category: Davies GJ]] | ||
[[Category: Hemsworth | [[Category: Hemsworth GR]] | ||
[[Category: King | [[Category: King D]] | ||
[[Category: Offen | [[Category: Offen WA]] | ||
[[Category: Roth | [[Category: Roth C]] | ||
[[Category: Varghese | [[Category: Varghese V]] | ||
[[Category: Vocadlo | [[Category: Vocadlo DJ]] | ||
[[Category: Willems | [[Category: Willems LI]] | ||