2ymk: Difference between revisions

<table><tr><td colspan='2'>[[2ymk]] is a 3 chain structure. The June 2013 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dermcidin''  by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2013_6 10.2210/rcsb_pdb/mom_2013_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YMK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2YMK FirstGlance]. <br>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2ymk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ymk OCA], [http://pdbe.org/2ymk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ymk RCSB], [http://www.ebi.ac.uk/pdbsum/2ymk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ymk ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/DCD_HUMAN DCD_HUMAN]] DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity.<ref>PMID:17448443</ref>  Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.<ref>PMID:17448443</ref>