2yf0: Difference between revisions

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<StructureSection load='2yf0' size='340' side='right'caption='[[2yf0]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
<StructureSection load='2yf0' size='340' side='right'caption='[[2yf0]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2yf0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YF0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2YF0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2yf0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YF0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2yf0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yf0 OCA], [http://pdbe.org/2yf0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yf0 RCSB], [http://www.ebi.ac.uk/pdbsum/2yf0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yf0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yf0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yf0 OCA], [https://pdbe.org/2yf0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yf0 RCSB], [https://www.ebi.ac.uk/pdbsum/2yf0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yf0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MTMR6_HUMAN MTMR6_HUMAN]] Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells.<ref>PMID:15831468</ref> <ref>PMID:16847315</ref>   
[[https://www.uniprot.org/uniprot/MTMR6_HUMAN MTMR6_HUMAN]] Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells.<ref>PMID:15831468</ref> <ref>PMID:16847315</ref>   


==See Also==
==See Also==

Revision as of 15:28, 27 April 2022

Human Myotubularin related protein 6 (MTMR6)Human Myotubularin related protein 6 (MTMR6)

Structural highlights

2yf0 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[MTMR6_HUMAN] Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells.[1] [2]

See Also

References

  1. ↑ Srivastava S, Li Z, Lin L, Liu G, Ko K, Coetzee WA, Skolnik EY. The phosphatidylinositol 3-phosphate phosphatase myotubularin- related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1. Mol Cell Biol. 2005 May;25(9):3630-8. PMID:15831468 doi:http://dx.doi.org/10.1128/MCB.25.9.3630-3638.2005
  2. ↑ Srivastava S, Ko K, Choudhury P, Li Z, Johnson AK, Nadkarni V, Unutmaz D, Coetzee WA, Skolnik EY. Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells. Mol Cell Biol. 2006 Aug;26(15):5595-602. PMID:16847315 doi:http://dx.doi.org/10.1128/MCB.00352-06

2yf0, resolution 2.65Å

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OCA
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