Major histocompatibility complex: Difference between revisions

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 == Function ==
-''' Major Histocompatibility Complex''' (MHC) are part of the adaptive immune system.  MHC molecules display peptides from degraded proteins on the host cell’s surface.  T cell or natural killer receptors recognize the MHC:peptide and activate the immune response.<br />
+''' Major Histocompatibility Complex''' (MHC) molecules bind peptides derived from degraded proteins and present these peptides on the surface of the cell. T-cells or natural killer receptors recognize the MHC:peptide complex and trigger an immune response if the presented peptide (“antigen”) is suggestive of a pathogenic or foreign protein. Thus, MHC molecules allow for immune system detection of intracellular activity, making them an essential part of the organism’s immune system.
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 *  '''MHC class I''' ([[Major Histocompatibility Complex Class I]]) are found in all nucleated cells.  These cell surface proteins display peptides from cellular intrinsic proteins<ref>PMID:18675588</ref>.  For more details see <br />
 *[[Effect of HCMV on Major Histocompatibility Complex Class I]]<br />