2x44: Difference between revisions
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<StructureSection load='2x44' size='340' side='right'caption='[[2x44]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='2x44' size='340' side='right'caption='[[2x44]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2x44]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2x44]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X44 FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ah1|1ah1]], [[1h6e|1h6e]], [[1i8l|1i8l]], [[1i85|1i85]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ah1|1ah1]], [[1h6e|1h6e]], [[1i8l|1i8l]], [[1i85|1i85]]</div></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x44 OCA], [https://pdbe.org/2x44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x44 RCSB], [https://www.ebi.ac.uk/pdbsum/2x44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x44 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
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</div> | </div> | ||
<div class="pdbe-citations 2x44" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 2x44" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[CTLA-4|CTLA-4]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 13:45, 13 April 2022
Structure of a strand-swapped dimeric form of CTLA-4Structure of a strand-swapped dimeric form of CTLA-4
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedWe present the crystal structure of an immunoglobulin light-chain-like domain, CTLA-4, as a strand-swapped dimer displaying cis-trans proline isomerisation and native-like hydrogen bonding. We also show that CTLA-4 can form amyloid-like fibres and amorphous deposits explainable by the same strand swapping. Our results suggest a molecular basis for the pathological aggregation of immunoglobulin domains and why amyloid-like fibres are more often composed of homologous rather than heterologous subunits. Domain metastability: a molecular basis for immunoglobulin deposition?,Sonnen AF, Yu C, Evans EJ, Stuart DI, Davis SJ, Gilbert RJ J Mol Biol. 2010 Jun 4;399(2):207-13. Epub 2010 Apr 13. PMID:20394753[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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