NudT16: Difference between revisions
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==Introduction== | ==Introduction== | ||
NudT16 is a | NudT16 is a member of the Nudix superfamily of hydrolases which break a phosphoester bond between the two phosphates in nucleoside diphosphate-linked to moiety X proteins resulting in a nucleoside monophosphate (NMP) and a phosphate linked to moiety X. Nudix hydrolases are characterized by a catalytically relevant Nudix box consisting of 23 highly conserved residues (G1Z2-6E7Z8-14R15E16U17Z18E19E20Z21G22U23 where Z is any amino acid and U is an aliphatic and hydrophobic residue). While NudT16 was initially described as a nuclear RNA and cytoplasmic mRNA decapping enzyme, further studies have shown that it also effectively hydrolyzes inosine diphsophate (IDP) and its hazardous deoxyribose cognate (dIDP) into inosine monophsophate (IMP) and deoxy inosine monophosphate (dIMP), respectively [1]. NudT16 has also been shown to regulate levels of 53BP1, an adaptor protein that recruits other proteins to the site of a DNA breakage, through hydrolytic removal of ADP-ribose from ADP-ribosylated 53BP1 [2]. | ||
==Structure== | ==Structure== | ||
Revision as of 00:32, 1 July 2020
IntroductionIntroduction
NudT16 is a member of the Nudix superfamily of hydrolases which break a phosphoester bond between the two phosphates in nucleoside diphosphate-linked to moiety X proteins resulting in a nucleoside monophosphate (NMP) and a phosphate linked to moiety X. Nudix hydrolases are characterized by a catalytically relevant Nudix box consisting of 23 highly conserved residues (G1Z2-6E7Z8-14R15E16U17Z18E19E20Z21G22U23 where Z is any amino acid and U is an aliphatic and hydrophobic residue). While NudT16 was initially described as a nuclear RNA and cytoplasmic mRNA decapping enzyme, further studies have shown that it also effectively hydrolyzes inosine diphsophate (IDP) and its hazardous deoxyribose cognate (dIDP) into inosine monophsophate (IMP) and deoxy inosine monophosphate (dIMP), respectively [1]. NudT16 has also been shown to regulate levels of 53BP1, an adaptor protein that recruits other proteins to the site of a DNA breakage, through hydrolytic removal of ADP-ribose from ADP-ribosylated 53BP1 [2].
StructureStructure
NudT16 is a dimer
Your Heading Here (maybe something like 'Structure')Your Heading Here (maybe something like 'Structure')
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FunctionFunction
DiseaseDisease
RelevanceRelevance
Structural highlightsStructural highlights
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