5k0n: Difference between revisions

<table><tr><td colspan='2'>[[5k0n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K0N FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6P0:5-[1-(4-METHOXYPHENYL)CYCLOPROPYL]-1,3-DIMETHYL-1H,2H-3,4-BIPYRAZOLE'>6P0</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k0n OCA], [https://pdbe.org/5k0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k0n RCSB], [https://www.ebi.ac.uk/pdbsum/5k0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k0n ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/COMT_RAT COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

[[Category: Rattus norvegicus]]

[[Category: Ehler A]]

[[Category: Rodriguez-Sarmiento RM]]