1by2: Difference between revisions

Revision as of 19:53, 30 June 2008

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File:1by2.png

Template:STRUCTURE 1by2

STRUCTURE OF M2BP SCAVENGER RECEPTOR CYSTEINE-RICH DOMAINSTRUCTURE OF M2BP SCAVENGER RECEPTOR CYSTEINE-RICH DOMAIN

Template:ABSTRACT PUBMED 10074941

About this StructureAbout this Structure

1BY2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of a scavenger receptor cysteine-rich domain sheds light on an ancient superfamily., Hohenester E, Sasaki T, Timpl R, Nat Struct Biol. 1999 Mar;6(3):228-32. PMID:10074941

Page seeded by OCA on Mon Jun 30 19:53:57 2008

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-'''STRUCTURE OF M2BP SCAVENGER RECEPTOR CYSTEINE-RICH DOMAIN'''
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-==Overview==
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-Scavenger receptor cysteine-rich (SRCR) domains are found widely in cell surface molecules and in some secreted proteins, where they are thought to mediate ligand binding. We have determined the crystal structure at 2.0 A resolution of the SRCR domain of Mac-2 binding protein (M2BP), a tumor-associated antigen and matrix protein. The structure reveals a curved six-stranded beta-sheet cradling an alpha-helix. Structure-based sequence alignment demonstrates that the M2BP SRCR domain is a valid template for the entire SRCR protein superfamily. This allows an interpretation of previous mutagenesis data on ligand binding to the lymphocyte receptor CD6.
+The line below this paragraph, {{ABSTRACT_PUBMED_10074941}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_10074941}}
 ==About this Structure==
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 [[Category: Scavenger receptor]]
 [[Category: Tumour-associated antigen]]
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