1bnt: Difference between revisions

Revision as of 19:26, 30 June 2008

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File:1bnt.png

Template:STRUCTURE 1bnt

CARBONIC ANHYDRASE II INHIBITORCARBONIC ANHYDRASE II INHIBITOR

Template:ABSTRACT PUBMED 9865942

About this StructureAbout this Structure

1BNT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structural analysis of inhibitor binding to human carbonic anhydrase II., Boriack-Sjodin PA, Zeitlin S, Chen HH, Crenshaw L, Gross S, Dantanarayana A, Delgado P, May JA, Dean T, Christianson DW, Protein Sci. 1998 Dec;7(12):2483-9. PMID:9865942

Page seeded by OCA on Mon Jun 30 19:26:07 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 {{STRUCTURE_1bnt|  PDB=1bnt  |  SCENE=  }}
-'''CARBONIC ANHYDRASE II INHIBITOR'''
+===CARBONIC ANHYDRASE II INHIBITOR===
-==Overview==
+<!--
-X-ray crystal structures of carbonic anhydrase II (CAII) complexed with sulfonamide inhibitors illuminate the structural determinants of high affinity binding in the nanomolar regime. The primary binding interaction is the coordination of a primary sulfonamide group to the active site zinc ion. Secondary interactions fine-tune tight binding in regions of the active site cavity &gt;5 A away from zinc, and this work highlights three such features: (1) advantageous conformational restraints of a bicyclic thienothiazene-6-sulfonamide-1,1-dioxide inhibitor skeleton in comparison with a monocyclic 2,5-thiophenedisulfonamide skeleton; (2) optimal substituents attached to a secondary sulfonamide group targeted to interact with hydrophobic patches defined by Phe131, Leu198, and Pro202; and (3) optimal stereochemistry and configuration at the C-4 position of bicyclic thienothiazene-6-sulfonamides; the C-4 substituent can interact with His64, the catalytic proton shuttle. Structure-activity relationships rationalize affinity trends observed during the development of brinzolamide (Azopt), the newest carbonic anhydrase inhibitor approved for the treatment of glaucoma.
+The line below this paragraph, {{ABSTRACT_PUBMED_9865942}}, adds the Publication Abstract to the page
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+{{ABSTRACT_PUBMED_9865942}}
 ==About this Structure==
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 [[Category: Lyase]]
 [[Category: Zinc enzyme]]
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