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==Structure of SARS-CoV-2 Nucleocapsid dimerization domain, P21 form== | ==Structure of SARS-CoV-2 Nucleocapsid dimerization domain, P21 form== | ||
<StructureSection load='6wzq' size='340' side='right'caption='[[6wzq]]' scene=''> | <StructureSection load='6wzq' size='340' side='right'caption='[[6wzq]], [[Resolution|resolution]] 1.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WZQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WZQ FirstGlance]. <br> | <table><tr><td colspan='2'>[[6wzq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/2019-ncov 2019-ncov]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WZQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WZQ FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wzq OCA], [http://pdbe.org/6wzq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wzq RCSB], [http://www.ebi.ac.uk/pdbsum/6wzq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wzq ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6wxo|6wxo]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wzq OCA], [http://pdbe.org/6wzq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wzq RCSB], [http://www.ebi.ac.uk/pdbsum/6wzq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wzq ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/NCAP_SARS2 NCAP_SARS2]] Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: 2019-ncov]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Corbett | [[Category: Corbett, K D]] | ||
[[Category: Ye Q]] | [[Category: Ye, Q]] | ||
[[Category: Covid-19]] | |||
[[Category: Nucleocapsid]] | |||
[[Category: Rna binding]] | |||
[[Category: Sars-cov-2]] | |||
[[Category: Viral protein]] | |||
Revision as of 13:49, 17 June 2020
Structure of SARS-CoV-2 Nucleocapsid dimerization domain, P21 formStructure of SARS-CoV-2 Nucleocapsid dimerization domain, P21 form
Structural highlights
Function[NCAP_SARS2] Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. |
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