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| [[Image:1bcm.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1bcm| PDB=1bcm | SCENE= }} | | {{STRUCTURE_1bcm| PDB=1bcm | SCENE= }} |
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| '''BACTERIOPHAGE MU TRANSPOSASE CORE DOMAIN WITH 2 MONOMERS PER ASYMMETRIC UNIT'''
| | ===BACTERIOPHAGE MU TRANSPOSASE CORE DOMAIN WITH 2 MONOMERS PER ASYMMETRIC UNIT=== |
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| ==Overview==
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| The crystal structure of the core domain of bacteriophage Mu transposase, MuA, has been determined at 2.4 A resolution. The first of two subdomains contains the active site and, despite very limited sequence homology, exhibits a striking similarity to the core domain of HIV-1 integrase, which carries out a similar set of biochemical reactions. It also exhibits more limited similarity to other nucleases, RNase H and RuvC. The second, a beta barrel, connects to the first subdomain through several contacts. Three independent determinations of the monomer structure from two crystal forms all show the active site held in a similar, apparently inactive configuration. The enzymatic activity of MuA is known to be activated by formation of a DNA-bound tetramer of the protein. We propose that the connections between the two subdomains may be involved in the cross-talk between the active site and the other domains of the transposase that controls the activity of the protein. | | The line below this paragraph, {{ABSTRACT_PUBMED_7628012}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 7628012 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_7628012}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Integrase]] | | [[Category: Integrase]] |
| [[Category: Polynucleotidyl transferase]] | | [[Category: Polynucleotidyl transferase]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:20:37 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:50:22 2008'' |