1bc7: Difference between revisions

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-[[Image:1bc7.gif|left|200px]]
+{{Seed}}
+[[Image:1bc7.png|left|200px]]
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 {{STRUCTURE_1bc7|  PDB=1bc7  |  SCENE=  }}
-'''SERUM RESPONSE FACTOR ACCESSORY PROTEIN 1A (SAP-1)/DNA COMPLEX'''
+===SERUM RESPONSE FACTOR ACCESSORY PROTEIN 1A (SAP-1)/DNA COMPLEX===
-==Overview==
+<!--
-SAP-1 is a member of the Ets transcription factors and cooperates with SRF protein to activate transcription of the c-fos protooncogene. The crystal structures of the conserved ETS domain of SAP-1 bound to DNA sequences from the E74 and c-fos promoters reveal that a set of conserved residues contact a GGA core DNA sequence. Discrimination for sequences outside this core is mediated by DNA contacts from conserved and nonconserved protein residues and sequence-dependent DNA structural properties characteristic of A-form DNA structure. Comparison with the related PU.1/DNA and GABPalpha/beta/DNA complexes provides general insights into DNA discrimination between Ets proteins. Modeling studies of a SAP-1/SRF/DNA complex suggest that SRF may modulate SAP-1 binding to DNA by interacting with its ETS domain.
+The line below this paragraph, {{ABSTRACT_PUBMED_9734357}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9734357 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9734357}}
 ==About this Structure==
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 [[Category: Ets domain]]
 [[Category: Winged helix-turn-helix]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:19:41 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 18:48:40 2008''