Activin receptor: Difference between revisions
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Michal Harel (talk | contribs) No edit summary |
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<StructureSection load=' | <StructureSection load='3mtf' size='340' side='right' caption='Caption for this structure' scene=''> | ||
<ref>PMID:21638687</ref> to the rescue. | <ref>PMID:21638687</ref> to the rescue. | ||
== Function == | == Function == | ||
'''Activin receptors''' (Acvr) are integral to the activin and myostatin signalling pathway. Binding of activin to the Acvr on muscle cell membrane leads to enhanced muscle protein breakdown and debilitating loss of muscle mass and functional capacity<ref>PMID:23721881</ref>. | |||
== Disease == | == Disease == | ||
A mutation in Acrv1 exists in individuals with the rare developmental disorder fibrodysplasia ossificans progressiva<ref>PMID:28918311</ref>. | |||
== Relevance == | == Relevance == | ||
Increased activin/Acvr2 signalling links aging and heart failure pathobiology and that targeted inhibition of this catabolic pathway may form a therapeutic strategy for multiple forms of hear failure<ref>PMID:30842316</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
*Activin receptor type 1 or Activin receptor-like type 2 or Serine/threonine-protein kinase receptor R1 or ALK2 | *Activin receptor type 1 or Activin receptor-like type 2 or Serine/threonine-protein kinase receptor R1 or ALK2 or BMP type 1 receptor kinase | ||
**[[5oxg]] - hAcvr1 kinase domain 172-499 + inhibitor - human<br /> | **[[5oxg]] - hAcvr1 kinase domain 172-499 + inhibitor - human<br /> | ||